Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MultiCook: A Tool That Improves Accuracy of HLA Imputation by Combining Probabilities From Multiple Reference Panels and Methods.

HLA - 1 May 2025

Kim Hakin, Lim Hyunjoon, Han Buhm

Abstract excerpt

HLA molecules are produced by genes within the Major Histocompatibility Complex (MHC). Although the identification of HLA genotype is costly, fortunately, recent computational methods have made it possible to impute HLA genotypes using inexpensive single nucleotide polymorphism (SNP) markers. These imputation methods perform well if ethnicity-matched reference panels are provided. However, the availability of...

Read the complete abstract on PubMed

Topics

Humans
HLA Antigens
Polymorphism, Single Nucleotide
Software
Genotype
Alleles
Gene Frequency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Asian People

Histocompatibility Testing

Computational Biology

Source

Open in PubMed Open full text

Identifiers

PMID: 40326750
DOI: 10.1111/tan.70153
PMCID: PMC12054343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MultiCook: A Tool That Improves Accuracy of HLA Imputation by Combining Probabilities From Multiple Reference Panels and Methods.PMID 40326750Read ↗

HLA-IMPUTER: an easy to use web application for HLA imputation and association analysis using population-specific reference panels.Semantic proximity Read ↗

A multi-ethnic reference panel to impute HLA classical and non-classical class I alleles in admixed samples: Testing imputation accuracy in an admixed sample from Brazil.Semantic proximity Read ↗

Meta-imputation: An efficient method to combine genotype data after imputation with multiple reference panels.Semantic proximity Read ↗

Multi-population classical HLA type imputation.Semantic proximity Read ↗

Accurate multi-population imputation of MICA, MICB, HLA-E, HLA-F and HLA-G alleles from genome SNP data.Semantic proximity Read ↗

Accurate multi-population imputation of MICA, MICB, HLA-E, HLA-F and HLA-G alleles from genome SNP dataSemantic proximity Read ↗

Optimal HLA imputation of admixed population with dimension reductionSemantic proximity Read ↗

A statistical genetics guide to identifying HLA alleles driving complex diseaseSemantic proximity Read ↗

18th International HLA and Immunogenetics Workshop: Report on the SNP-HLA Reference Consortium (SHLARC) component.Semantic proximity Read ↗

Increasing accuracy of HLA imputation by a population-specific reference panel in a FinnGen biobank cohortSemantic proximity Read ↗

Evaluation of imputation performance of multiple reference panels in a Pakistani population.Semantic proximity Read ↗

Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.