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Article

An Argonaute transports siRNAs from the cytoplasm to the nucleus.

Science (New York, N.Y.) - 25 Jul 2008

Guang Shouhong, Bochner Aaron F, Pavelec Derek M, Burkhart Kirk B, Harding Sandra, Lachowiec Jennifer, Kennedy Scott

Abstract excerpt

Ribonucleoprotein complexes consisting of Argonaute-like proteins and small regulatory RNAs function in a wide range of biological processes. Many of these small regulatory RNAs are predicted to act, at least in part, within the nucleus. We conducted a genetic screen to identify factors essential for RNA interference (RNAi) in nuclei of Caenorhabditis elegans and identified the Argonaute protein NRDE-3. In the...

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Identifiers

PMID: 18653886
DOI: 10.1126/science.1157647
PMCID: PMC2771369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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