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Chaperone-mediated autophagy: roles in neurodegeneration

21 Sept 2014

Abstract excerpt

Chaperone-mediated autophagy (CMA) selectively delivers cytosolic proteins with an exposed CMA-targeting motif to lysosomes for degradation and plays an important role in protein quality control and cellular homeostasis. A growing body of evidence supports the hypothesis that CMA dysfunction may be involved in the pathogenic process of neurodegenerative diseases. Both down-regulation and compensatory...

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PMID: 25276349
DOI: 10.1186/2047-9158-3-20

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