Article
Mutations affecting the activity of the Shiga-like toxin I A-chain.
Biochemistry - 31 Mar 1992
Deresiewicz R L, Calderwood S B, Robertus J D, Collier R J
Abstract excerpt
Like ricin, Escherichia coli Shiga-like toxin I (SLT-I) inactivates eukaryotic ribosomes by catalytically depurinating adenosine 4324 in 28S rRNA. Although the primary structure of the enzymatic portion of the molecule (Slt-IA) is known to contain regions of significant homology to the ricin A chain (RTA), and although certain residues have been implicated in catalysis, the crystal structure of Slt-IA has not...
Topics
- Amino Acid Sequence
- Bacterial Toxins
- Base Sequence
- Chromosome Deletion
- Escherichia coli
- Genetic Vectors
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutagenesis, Site-Directed
- Mutation
- Protein Synthesis Inhibitors