Construction and characterization of an isogenic slt-ii deletion mutant of enterohemorrhagic Escherichia coli.

doi:10.1128/IAI.66.5.2337-2341.1998

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Article

Construction and characterization of an isogenic slt-ii deletion mutant of enterohemorrhagic Escherichia coli.

Infection and immunity - 1 May 1998

Gunzer F, Bohn U, Fuchs S, Mühldorfer I, Hacker J, Tzipori S, Donohue-Rolfe A

Abstract excerpt

Enterohemorrhagic Escherichia coli (EHEC) produces Shiga-like toxins (SLT), potent protein synthesis inhibitors. To further dissect the role of SLT-II in the course of disease, we have constructed E. coli TUV86-2, an isogenic SLT-II-negative mutant of EHEC strain 86-24. The slt-ii gene was inacti...

Topics

Animals
Bacterial Toxins
Enterotoxins
Escherichia coli
Mice
Mice, Inbred BALB C
Mutation
Shiga Toxin 2

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