Heat mutagenesis in bacteriophage T4: another walk down the transversion pathway.

Abstract excerpt

Extracellular nonreplicating bacteriophage T4 particles accumulate mutations as functions of temperature, time, pH, and ionic environment via two mechanisms: 5-hydroxymethylcytidine deamination produces G.C----A.T transitions while a guanosine modification produces transversions. Neither frameshift mutations nor mutations at A.T base pairs are appreciably induced. We now show that heat induces G.C----T.A...

Topics

• Base Composition
• Genes, Viral
• Hot Temperature
• Mutation
• T-Phages