Article
T4 phage evolution data in terms of a time-dependent Topal-Fresco mechanism.
Biochemical genetics - 1 Dec 1994
Cooper W G
Abstract excerpt
A physical interpretation of the Topal-Fresco [Nature 263, 285 (1976)] model for spontaneous base substitutions suggests that hydrogen-bonded DNA protons satisfy the criteria for a classical noninteracting isolated system. Accessible states for duplex G-C protons include the keto-amino state and the six complementary enol-imine isomers. Hydrogen-bonded enol and imine protons occupy symmetric double-minima created...
Topics
- Amino Acids
- Bacteriophage T4
- Base Composition
- Base Sequence
- Biological Evolution
- Codon
- DNA Replication
- DNA, Viral
- Genetic Code
- Hydrogen Bonding
- Models, Genetic
- Mutation