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Article

T4 phage evolution data in terms of a time-dependent Topal-Fresco mechanism.

Biochemical genetics - 1 Dec 1994

Cooper W G

Abstract excerpt

A physical interpretation of the Topal-Fresco [Nature 263, 285 (1976)] model for spontaneous base substitutions suggests that hydrogen-bonded DNA protons satisfy the criteria for a classical noninteracting isolated system. Accessible states for duplex G-C protons include the keto-amino state and the six complementary enol-imine isomers. Hydrogen-bonded enol and imine protons occupy symmetric double-minima created...

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PMID: 7748155
DOI: 10.1007/BF00566059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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