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Article

Cytosine deamination and the precipitous decline of spontaneous mutation during Earth's history.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2016

Lewis Charles A, Crayle Jesse, Zhou Shuntai, Swanstrom Ronald, Wolfenden Richard

Abstract excerpt

The hydrolytic deamination of cytosine and 5-methylcytosine residues in DNA appears to contribute significantly to the appearance of spontaneous mutations in microorganisms and in human disease. In the present work, we examined the mechanism of cytosine deamination and the response of the uncatalyzed reaction to changing temperature. The positively charged 1,3-dimethylcytosinium ion was hydrolyzed at a rate...

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Identifiers

PMID: 27382162
DOI: 10.1073/pnas.1607580113
PMCID: PMC4961170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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