Article
Susceptibility to childhood-onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci.
Arthritis and rheumatism - 1 Jun 2013
Prahalad Sampath, Conneely Karen N, Jiang Yunxuan, Sudman Marc, Wallace Carol A, Brown Milton R, Ponder Lori A, Rohani-Pichavant Mina, Zwick Michael E, Cutler David J, Angeles-Han Sheila T, Vogler Larry B, Kennedy Christine, Rouster-Stevens Kelly, Wise Carol A, Punaro Marilynn, Reed Ann M, Mellins Elizabeth D, Bohnsack John F, Glass David N, Thompson Susan D
Abstract excerpt
OBJECTIVE: Children with childhood-onset rheumatoid arthritis (RA) include those with rheumatoid factor or anti-citrullinated protein antibody-positive juvenile idiopathic arthritis. To test the hypothesis that adult-onset RA-associated variants are also associated with childhood-onset RA, we investigated RA-associated variants at 5 loci in a cohort of patients with childhood-onset RA. We also assessed the...
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