Article
Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction.
Scientific reports - 1 Jan 2013
Carotenuto Marianeve, Pedone Emilia, Diana Donatella, de Antonellis Pasqualino, Džeroski Sašo, Marino Natascia, Navas Luigi, Di Dato Valeria, Scoppettuolo Maria Nunzia, Cimmino Flora, Correale Stefania, Pirone Luciano, Monti Simona Maria, Bruder Elisabeth, Zenko Bernard, Slavkov Ivica, Pastorino Fabio, Ponzoni Mirco, Schulte Johannes H, Schramm Alexander, Eggert Angelika, Westermann Frank, Arrigoni Gianluigi, Accordi Benedetta, Basso Giuseppe, Saviano Michele, Fattorusso Roberto, Zollo Massimo
Abstract excerpt
Nm23-H1 is one of the most interesting candidate genes for a relevant role in Neuroblastoma pathogenesis. H-Prune is the most characterized Nm23-H1 binding partner, and its overexpression has been shown in different human cancers. Our study focuses on the role of the Nm23-H1/h-Prune protein complex in Neuroblastoma. Using NMR spectroscopy, we performed a conformational analysis of the h-Prune C-terminal to...
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