Article
Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV.
Genomics - 1 Apr 2006
Valentijn Linda J, Koster Jan, Versteeg Rogier
Abstract excerpt
NM23-H1 and NM23-H2 are neighboring genes on chromosome 17q. They encode nucleoside diphosphate kinases that have additional roles in signal transduction, transcription, and apoptosis. NM23-H1 expression is a strong marker for prognosis and metastatic behavior in many tumor types. A new bioinformatic tool, TranscriptView, identified read-through transcripts that start in the NM23-H1 gene and continue in the...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Biomarkers, Tumor
- Blotting, Western
- Cell Line, Tumor
- Cell Nucleus
- Chromosomes, Human, Pair 17
- Computational Biology
- Cytoplasm
- DNA, Neoplasm
- Exons
