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Article

Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis.

Cancer cell - 1 Feb 2004

D'Angelo Anna, Garzia Livia, André Alessandra, Carotenuto Pietro, Aglio Veruska, Guardiola Ombretta, Arrigoni Gianluigi, Cossu Antonio, Palmieri Giuseppe, Aravind L, Zollo Massimo

Abstract excerpt

We identify a new enzymatic activity underlying metastasis in breast cancer and describe its susceptibility to therapeutic inhibition. We show that human prune (h-prune), a phosphoesterase DHH family appertaining protein, has a hitherto unrecognized cyclic nucleotide phosphodiesterase activity effectively suppressed by dipyridamole, a phosphodiesterase inhibitor. h-prune physically interacts with nm23-H1, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14998490
DOI: 10.1016/s1535-6108(04)00021-2

Genes

DHH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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