Article
Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase.
Biochemistry - 9 Sept 2008
Tammenkoski Marko, Koivula Katja, Cusanelli Emilio, Zollo Massimo, Steegborn Clemens, Baykov Alexander A, Lahti Reijo
Abstract excerpt
The DHH superfamily human protein h-prune, a binding partner of the metastasis suppressor nm23-H1, is frequently overexpressed in metastatic cancers. From an evolutionary perspective, h-prune is very close to eukaryotic exopolyphosphatases. Here, we show for the first time that h-prune efficiently hydrolyzes short-chain polyphosphates (k cat of 3-40 s (-1)), including inorganic tripoly- and tetrapolyphosphates...
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