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Decoding the genetic influence of CT60 non-coding polymorphism in CTLA-4 gene and sCTLA-4 biomarker with rheumatoid arthritis in the Indian population.

Molecular biology reports - 28 Sept 2024

Shamala V, Asha Devi S

Abstract excerpt

BACKGROUND: Cytoplasmic T Lymphocyte Antigen - 4 (CTLA-4) gene encodes an immunoregulatory receptor expressed on surface of activated T-cells to mediate peripheral tolerance against self-antigen. It suppresses auto-reactive T-cell proliferation either by inactivation or apoptosis of T-cells. The CTLA-4 mRNA undergoes alternative splicing to synthesize a native soluble form of CTLA-4 (sCTLA-4) protein, which lacks...

Topics

Adult
Female
Humans
Male
Middle Aged
3' Untranslated Regions
Alleles
Arthritis, Rheumatoid
Biomarkers
Case-Control Studies
CTLA-4 Antigen
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genotype

India

Polymorphism, Single Nucleotide

South Asian People

Source

Identifiers

PMID: 39340674
DOI: 10.1007/s11033-024-09949-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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