CTLA-4 +49 G/A Polymorphism Confers Autoimmune Disease Risk: An Updated Meta-Analysis.

doi:10.1089/gtmb.2016.0335

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Article

CTLA-4 +49 G/A Polymorphism Confers Autoimmune Disease Risk: An Updated Meta-Analysis.

Genetic testing and molecular biomarkers - 1 Apr 2017

Wang Ke, Zhu Qin, Lu Yunjie, Lu Hao, Zhang Feng, Wang Xuehao, Fan Ye

Abstract excerpt

BACKGROUND: Cytotoxic T lymphocyte antigen-4 (CTLA-4) plays a pivotal role in immune homeostasis. Dysregulated expression of CTLA-4 leads to many autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes (T1D). There has been a controversial association between the CTLA-4 +49 G/A SNP (rs231775) and autoimmune diseases. Therefore, this meta-analysis was performed to...

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PMID: 28384040
DOI: 10.1089/gtmb.2016.0335

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