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Article

A Gaussian copula approach for the analysis of secondary phenotypes in case-control genetic association studies.

Biostatistics (Oxford, England) - 1 Jul 2012

He Jing, Li Hongzhe, Edmondson Andrew C, Rader Daniel J, Li Mingyao

Abstract excerpt

In many case-control genetic association studies, a set of correlated secondary phenotypes that may share common genetic factors with disease status are collected. Examination of these secondary phenotypes can yield valuable insights about the disease etiology and supplement the main studies. However, due to unequal sampling probabilities between cases and controls, standard regression analysis that assesses the...

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PMID: 21933777
DOI: 10.1093/biostatistics/kxr025
PMCID: PMC3372941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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