Article
Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan.
Kidney international - 1 Feb 2010
Tsaih Shirng-Wern, Pezzolesi Marcus G, Yuan Rong, Warram James H, Krolewski Andrzej S, Korstanje Ron
Abstract excerpt
Aging in the kidney can cause albuminuria, and discovering molecular mechanisms responsible for this might offer a new perspective on the etiology of this abnormality. Haplotype association mapping in the mouse is a novel approach which uses the haplotypes of the relatively closely related mouse inbred strains and the phenotypic variation among these strains to find associations between haplotypes and phenotype....
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