Article
Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).
PLoS genetics - 1 Jun 2011
Reiner Alexander P, Lettre Guillaume, Nalls Michael A, Ganesh Santhi K, Mathias Rasika, Austin Melissa A, Dean Eric, Arepalli Sampath, Britton Angela, Chen Zhao, Couper David, Curb J David, Eaton Charles B, Fornage Myriam, Grant Struan F A, Harris Tamara B, Hernandez Dena, Kamatini Naoyuki, Keating Brendan J, Kubo Michiaki, LaCroix Andrea, Lange Leslie A, Liu Simin, Lohman Kurt, Meng Yan, Mohler Emile R, Musani Solomon, Nakamura Yusuke, O'Donnell Christopher J, Okada Yukinori, Palmer Cameron D, Papanicolaou George J, Patel Kushang V, Singleton Andrew B, Takahashi Atsushi, Tang Hua, Taylor Herman A, Taylor Kent, Thomson Cynthia, Yanek Lisa R, Yang Lingyao, Ziv Elad, Zonderman Alan B, Folsom Aaron R, Evans Michele K, Liu Yongmei, Becker Diane M, Snively Beverly M, Wilson James G
Abstract excerpt
Total white blood cell (WBC) and neutrophil counts are lower among individuals of African descent due to the common African-derived "null" variant of the Duffy Antigen Receptor for Chemokines (DARC) gene. Additional common genetic polymorphisms were recently associated with total WBC and WBC sub-type levels in European and Japanese populations. No additional loci that account for WBC variability have been...
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