Article
Inferring patient to patient transmission of Mycobacterium tuberculosis from whole genome sequencing data.
BMC infectious diseases - 27 Feb 2013
Bryant Josephine M, Schürch Anita C, van Deutekom Henk, Harris Simon R, de Beer Jessica L, de Jager Victor, Kremer Kristin, van Hijum Sacha A F T, Siezen Roland J, Borgdorff Martien, Bentley Stephen D, Parkhill Julian, van Soolingen Dick
Abstract excerpt
BACKGROUND: Mycobacterium tuberculosis is characterised by limited genomic diversity, which makes the application of whole genome sequencing particularly attractive for clinical and epidemiological investigation. However, in order to confidently infer transmission events, an accurate knowledge of the rate of change in the genome over relevant timescales is required. METHODS: We attempted to estimate a molecular...
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