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Article

Multiple effects on liver-specific gene expression in albino lethal mice caused by deficiency of an enzyme in tyrosine metabolism.

Journal of cell science. Supplement - 1 Jan 1992

Kelsey G, Ruppert S, Schedl A, Schmid E, Thies E, Schütz G

Abstract excerpt

alf/hsdr-1 is a locus in the mouse defined by albino deletions to be essential for neonatal viability. Homozygous deletion of alf/hsdr-1 leads to a pleiotropic phenotype in liver and kidney, including impaired perinatal activation of hormone-dependent genes, and the induction of detoxifying enzymes and early-response genes. To elucidate the molecular basis of this complex phenotype, we have identified the gene...

Topics

Animals
Gene Expression Regulation
Genes, Lethal
Hydrolases
Liver
Liver Failure
Mice
Phenotype
Tyrosine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1297646
DOI: 10.1242/jcs.1992.supplement_16.14

Genes

FAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1297646-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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