Article
Chromosomal deletions around the albino locus in the mouse cause loss of hormone-inducible expression of the unlinked structural gene encoding cytosolic aspartate aminotransferase.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 1995
Lia M, Barouki R, Waelsch S G
Abstract excerpt
A group of genes in the mouse encoding liver-specific gluconeogenic enzymes and mapping on different chromosomes lose their normal competence for hormone-inducible expression in animals homozygous for chromosomal deletions around the albino locus on chromosome 7. The basal expression of these same genes remains normal. In previous investigations, glucocorticoid hormones as well as their receptors were found to be...
Topics
- Albinism
- Animals
- Animals, Newborn
- Aspartate Aminotransferases
- Brain
- Brain Chemistry
- Chromosome Deletion
- Cyclic AMP
- Cytosol
- Dexamethasone
- Enzyme Induction