Rescue of mice homozygous for lethal albino deletions: implications for an animal model for the human liver disease tyrosinemia type 1.

doi:10.1101/gad.7.12a.2285

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Article

Rescue of mice homozygous for lethal albino deletions: implications for an animal model for the human liver disease tyrosinemia type 1.

Genes & development - 1 Dec 1993

Kelsey G, Ruppert S, Beermann F, Grund C, Tanguay R M, Schütz G

Abstract excerpt

Mice homozygous for specific deletions around the albino locus on chromosome 7 die within the first few hours of birth. They have a complex phenotype in liver and kidney, which includes multiple changes in gene expression and ultrastructural abnormalities. On the basis of this phenotype, it was p...

Topics

Albinism
Animals
Disease Models, Animal
Gene Deletion
Gene Expression
Homozygote
Humans
Hydrolases
Hypoglycemia
Liver
Liver Diseases
Mice
Mice, Transgenic
Phenotype
Tyrosine

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