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Article

Deficiency of an enzyme of tyrosine metabolism underlies altered gene expression in newborn liver of lethal albino mice.

Genes & development - 1 Aug 1992

Ruppert S, Kelsey G, Schedl A, Schmid E, Thies E, Schütz G

Abstract excerpt

Mice homozygous for albino deletions encompassing the locus alf/hsdr-1 die shortly after birth. Lethality is thought to be the consequence of hypoglycemia, which results from the failure to activate hormone-dependent genes in liver and kidney encoding enzymes important for gluconeogenesis. Within the region in which alf/hsdr-1 has been defined by physical mapping, we identified the gene encoding...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Blotting, Southern
Cells, Cultured
DNA Probes
Gene Expression
Homozygote
Hydrolases
Liver
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

Molecular Sequence Data

Nucleic Acid Hybridization

Phenotype

Tyrosine

Source

Identifiers

PMID: 1644288
DOI: 10.1101/gad.6.8.1430

Genes

FAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1644288-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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