Article
3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing.
BMC cancer - 27 Feb 2013
Longati Paola, Jia Xiaohui, Eimer Johannes, Wagman Annika, Witt Michael-Robin, Rehnmark Stefan, Verbeke Caroline, Toftgård Rune, Löhr Matthias, Heuchel Rainer L
Abstract excerpt
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer related death. It is lethal in nearly all patients, due to an almost complete chemoresistance. Most if not all drugs that pass preclinical tests successfully, fail miserably in the patient. This raises the question whether traditional 2D cell culture is the correct tool for drug screening. The objective of this study is...
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