Article

Matrix Stiffness Influences Drug Resistance to Gemcitabine Analog and AZD 1775 Combination in PDAC Organoids

2025-06-09

Abstract excerpt

<h4>Background</h4> Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers, with limited therapeutic advancements and rapid development of treatment resistance. Fatty acid-conjugated gemcitabine analogs have shown improved antitumor efficacy. This study investigates the effects of gemcitabine conjugated with caprylic acid (Gemcitabine-8C) in combination with AZD 1775, a WEE1 inhibitor, using pati...

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Literature Corpus work: 0d827776-f85c-5491-bd66-e8f24de2e23b
DOI: 10.1101/2025.06.03.25328936

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