Article
Two-dimensional culture of human pancreatic adenocarcinoma cells results in an irreversible transition from epithelial to mesenchymal phenotype.
Laboratory investigation; a journal of technical methods and pathology - 1 Feb 2015
Kang Ya'an, Zhang Ran, Suzuki Rei, Li Shao-qiang, Roife David, Truty Mark J, Chatterjee Deyali, Thomas Ryan M, Cardwell James, Wang Yu, Wang Huamin, Katz Matthew H, Fleming Jason B
Abstract excerpt
Many commercially available cell lines have been in culture for ages, acquiring phenotypes that differ from the original cancers from which these cell lines were derived. Therefore, research on new cell lines could improve the success rates of translational research in cancer. We have developed methods for the isolation and culture of human pancreatic ductal adenocarcinoma (PDAC) cells from murine xenografts of...
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