Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite <i>Trypanosoma brucei</i>

Abstract excerpt

Almiramide C is a marine natural product with low micromolar activity against Leishmania donovani, the causative agent of leishmaniasis. We have now shown that almiramide C is also active against the related parasite Trypanosoma brucei, the causative agent of human African trypanosomiasis. A series of activity-based probes have been synthesized to explore both the molecular target of this compound series in T....

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