β-1,4-Galactosyltransferase III enhances invasive phenotypes via β1-integrin and predicts poor prognosis in neuroblastoma.

doi:10.1158/1078-0432.CCR-12-2367

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Article

β-1,4-Galactosyltransferase III enhances invasive phenotypes via β1-integrin and predicts poor prognosis in neuroblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2013

Chang Hsiu-Hao, Chen Chia-Hua, Chou Chih-Hsing, Liao Yung-Feng, Huang Miao-Juei, Chen Ya-Hsin, Wang Wei-Jen, Huang John, Hung Ji-Shiang, Ho Wan-Ling, Jeng Yung-Ming, Che Mei-Ieng, Lee Hsinyu, Lu Meng-Yao, Yang Yung-Li, Jou Shiann-Tarng, Lin Dong-Tsamn, Lin Kai-Hsin, Hsu Wen-Ming, Huang Min-Chuan

Abstract excerpt

PURPOSE: Neuroblastoma (NB) is a neural crest-derived tumor that commonly occurs in childhood. β-1,4-Galactosyltransferase III (B4GALT3) is highly expressed in human fetal brain and is responsible for the generation of poly-N-acetyllactosamine, which plays a critical role in tumor progression. We therefore investigated the expression and role of B4GALT3 in NB. EXPERIMENTAL DESIGN: We examined B4GALT3 expression...

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PMID: 23444218
DOI: 10.1158/1078-0432.CCR-12-2367

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