Learning smoothing models of copy number profiles using breakpoint annotations

Abstract excerpt

BACKGROUND: Many models have been proposed to detect copy number alterations in chromosomal copy number profiles, but it is usually not obvious to decide which is most effective for a given data set. Furthermore, most methods have a smoothing parameter that determines the number of breakpoints and must be chosen using various heuristics. RESULTS: We present three contributions for copy number profile smoothing...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genomic variations and chromosomal abnormalities
• Share to Genomics and Rare Diseases
• Share to Neuroblastoma Research and Treatments