Article
Mutations in the mitochondrial ATPase6 gene are frequent in human osteosarcoma.
Experimental and molecular pathology - 1 Feb 2013
Guo Xue-Guang, Liu Chang-Ting, Dai Huanzi, Guo Qiao-Nan
Abstract excerpt
To explore the polymorphisms and mutations of mitochondrial ATPase6 gene in Chinese patients with osteosarcoma and their possible association with carcinogenesis, direct DNA sequencing method was used to detect the variants of the mitochondrial ATPase6 gene in 39 patients with osteosarcoma. We found mutations of the mitochondrial ATPase6 gene in 24/39 (61.5%) of the tested osteosarcoma samples, and identified 27...
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