In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes

Abstract excerpt

RATIONALE: Repolarization alternans (RA) are associated with arrhythmogenesis. Animal studies have revealed potential mechanisms, but human-focused studies are needed. RA generation and frequency dependence may be determined by cell-to-cell variability in protein expression, which is regulated by genetic and external factors. OBJECTIVE: To characterize in vivo RA in human and to investigate in silico using human...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiac Arrhythmias and Treatments
• Share to Cardiac electrophysiology and arrhythmias
• Share to Ion channel regulation and function