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Article

Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations.

eLife - 23 Dec 2024

Zhou Xin, Wang Zhinuo Jenny, Camps Julia, Tomek Jakub, Santiago Alfonso, Quintanas Adria, Vazquez Mariano, Vaseghi Marmar, Rodriguez Blanca

Abstract excerpt

Sudden death after myocardial infarction (MI) is associated with electrophysiological heterogeneities and ionic current remodelling. Low ejection fraction (EF) is used in risk stratification, but its mechanistic links with pro-arrhythmic heterogeneities are unknown. We aim to provide mechanistic explanations of clinical phenotypes in acute and chronic MI, from ionic current remodelling to ECG and EF, using human...

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Identifiers

PMID: 39711335
DOI: 10.7554/eLife.93002
PMCID: PMC11668532

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