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Article

Estimation of CYP2C19 activity by the omeprazole hydroxylation index at a single point in time after intravenous and oral administration.

European journal of clinical pharmacology - 1 Nov 2007

Niioka Takenori, Uno Tsukasa, Sugimoto Katsuyoshi, Sugawara Kazunobu, Hayakari Makoto, Tateishi Tomonori

Abstract excerpt

OBJECTIVE: The purpose of this study was to identify the common time point to achieve hydroxylation index (HI: omeprazole plasma concentration/5-hydroxyomeprazole plasma concentration) reflecting AUCOPZ/AUC5OH-OPZ after intravenous (IV) and oral (PO) administration. METHODS: Twenty young and 28 elderly healthy subjects, including different CYP2C19 genotypes, were enrolled in the study. The young subjects received...

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Identifiers

PMID: 17701405
DOI: 10.1007/s00228-007-0331-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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