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Article

The enzymatic synthesis of lipid A: molecular structure and biologic function of monosaccharide precursors.

Reviews of infectious diseases - 1 Jan 2000

Raetz C R

Abstract excerpt

Certain Escherichia coli mutants, deficient in phosphatidylglycerol, accumulate novel, glucosamine-derived phospholipids that appear to be very early precursors of lipid A. The simplest of these, lipid X, is a derivative of glucosamine-1-phosphate substituted with beta-hydroxymyristoyl moieties at positions 2 and 3. The discovery of lipid X makes it possible to predict a biosynthetic pathway and a unified...

Topics

Animals
Disaccharides
Endotoxins
Escherichia coli
Lipid A
Mice
Mitogens
Monosaccharides
Mutation
Phosphatidylglycerols
Structure-Activity Relationship
Sugar Acids

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Identifiers

PMID: 6382553
DOI: 10.1093/clinids/6.4.463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6382553-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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