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Engineering low-endotoxin lipid A in a double auxotroph Pseudomonas aeruginosa to develop safer whole-cell vaccines.

Frontiers in cellular and infection microbiology - 1 Jan 2026

Fuentes-Valverde Víctor, García Patricia, Candela Ana, Santamarina-Fernández Rebeca, Avendaño-Ortiz José, Martínez-Alonso Emma, Oviaño Marina, Cantón Rafael, Arenas Jesús, Moscoso Miriam, Bou Germán

Abstract excerpt

Introduction: Pseudomonas aeruginosa is a highly adaptable Gram-negative bacterium causing severe respiratory infections, particularly in vulnerable populations. The rise of antimicrobial resistance highlights the urgent need for effective vaccines. We previously developed a live-attenuated vaccine candidate, PAO1 ΔmurI Δalr ΔdadX, a genetically stable double auxotrophic strain that exhibited dose-dependent...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42306526
DOI: 10.3389/fcimb.2026.1840122
PMCID: PMC13265386

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TLR4

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