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Article

Genetic variation in BDNF is associated with antipsychotic treatment resistance in patients with schizophrenia.

Schizophrenia research - 1 May 2013

Zhang Jian-Ping, Lencz Todd, Geisler Stephen, DeRosse Pamela, Bromet Evelyn J, Malhotra Anil K

Abstract excerpt

OBJECTIVE: Antipsychotic drugs are the mainstay of treatment for schizophrenia. However, a substantial proportion of patients are poorly responsive or resistant to first-line treatments, and clozapine treatment is often indicated. Therefore, we and others have used clozapine treatment as a proxy phenotype for antipsychotic treatment resistance in pharmacogenetic studies. In the present study, we utilized this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23433505
DOI: 10.1016/j.schres.2013.01.020
PMCID: PMC3622803

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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