Article
Association between the brain-derived neurotrophic factor Val66Met polymorphism and therapeutic response to olanzapine in schizophrenia patients.
Psychopharmacology - 1 Sept 2014
Nikolac Perkovic Matea, Nedic Erjavec Gordana, Zivkovic Maja, Sagud Marina, Uzun Suzana, Mihaljevic-Peles Alma, Kozumplik Oliver, Muck-Seler Dorotea, Pivac Nela
Abstract excerpt
RATIONALE: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a major role in neurogenesis and neuroplasticity, and in the modulation of several neurotransmitter systems including the dopaminergic system. There are mixed reports about the association between the BDNF Val66Met polymorphism, schizophrenia, and treatment response to antipsychotic drugs. OBJECTIVES: The present study evaluated the...
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