Article
An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients.
Neuroscience letters - 9 Oct 2003
Hong Chen-Jee, Yu Younger W-Y, Lin Ching-Hua, Tsai Shih-Jen
Abstract excerpt
A growing body of evidence suggests the involvement of brain-derived neurotrophic factor (BDNF) in both antipsychotic action and schizophrenia pathogenesis. The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with schizophrenia and clozapine's therapeutic response. To identify any genetic predisposition to schizophrenia, we studied the BDNF-gene Val66Met polymorphism in...
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