Article
Polymorphisms in Schizophrenia-Related Genes Are Potential Predictors of Antipsychotic Treatment Resistance and Refractoriness.
The international journal of neuropsychopharmacology - 28 Sept 2022
Zazueta Alejandra, Castillo Tito, Cavieres Álvaro, González René, Abarca Maximiliano, Nieto Rodrigo R, Deneken Javier, Araneda Cristian, Moya Pablo R, Bustamante M Leonor
Abstract excerpt
BACKGROUND: Approximately 30% of individuals with schizophrenia (SZ) are resistant to conventional antipsychotic drug therapy (AP). Of these, one-third are also resistant to the second-line treatment, clozapine. Treatment resistance and refractoriness are associated with increased morbidity and disability, making timely detection of these issues critical. Variability in treatment responsiveness is partly genetic,...
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