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Article

BDNF Val66Met polymorphism and clinical response to antipsychotic treatment in schizophrenia and schizoaffective disorder patients: a meta-analysis.

The pharmacogenomics journal - 1 Jun 2019

Huang Eric, Hettige Nuwan C, Zai Gwyneth, Tomasi Julia, Huang Justin, Zai Clement C, Pivac Nela, Nikolac Perkovic Matea, Tiwari Arun K, Kennedy James L

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) plays an important role in dopaminergic and serotonergic neurotransmission by modulating dopaminergic neuron differentiation and establishment. Multiple studies have analyzed the functional BDNF Val66Met variant in relation to antipsychotic response in schizophrenia (SCZ) patients, yielding mixed results. A meta-analysis was thus performed to examine the relationship...

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PMID: 30181602
DOI: 10.1038/s41397-018-0041-5

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