Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutation patterns and compound response in cancers.

BMB reports - 1 Feb 2013

He Ningning, Kim Nayoung, Yoon Sukjoon

Abstract excerpt

The use of various cancer cell lines can recapitulate known tumor-associated mutations and genetically define cancer subsets. This approach also enables comparative surveys of associations between cancer mutations and drug responses. Here, we analyzed the effects of ~40,000 compounds on cancer cell lines that showed diverse mutation-dependent sensitivity profiles. Over 1,000 compounds exhibited unique sensitivity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Cell Line, Tumor
Share to Cluster Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Factual

Share to Gene Expression Profiling

Share to Neoplasms

Share to Small Molecule Libraries

Share to Software

Source

Open in PubMed Open full text

Identifiers

PMID: 23433112
DOI: 10.5483/bmbrep.2013.46.2.226
PMCID: PMC4133857

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutation patterns and compound response in cancers.PMID 23433112Read ↗

Methods and resources to access mutation-dependent effects on cancer drug treatment.Semantic proximity Read ↗

Mutational signatures are markers of drug sensitivity of cancer cellsSemantic proximity Read ↗

mTCTScan: a comprehensive platform for annotation and prioritization of mutations affecting drug sensitivity in cancers.Semantic proximity Read ↗

Pan-Cancer Pharmacogenomic Analysis of Patient-Derived Tumor Cells Using Clinically Relevant Drug Exposures.Semantic proximity Read ↗

Mutational signatures are markers of drug sensitivity of cancer cells.Semantic proximity Read ↗

Somatic alterations as the basis for resistance to targeted therapies.Semantic proximity Read ↗

Interactive webtool for analyzing drug sensitivity and resistance associated with genetic signatures of cancer cell linesSemantic proximity Read ↗

Somatic Mutaome Profile in Human Cancer TissuesSemantic proximity Read ↗

From Mutational Mechanisms in Single Cells to Mutational Patterns in Cancer Genomes.Semantic proximity Read ↗

MACE: mutation-oriented profiling of chemical response and gene expression in cancers.Semantic proximity Read ↗

Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.Semantic proximity Read ↗

The mutational footprints of cancer therapies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.