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Article

Somatic alterations as the basis for resistance to targeted therapies.

The Journal of pathology - 1 Jan 2014

Blair Brian G, Bardelli Alberto, Park Ben Ho

Abstract excerpt

Recent advances in genetics and genomics have revealed new genes and pathways that are somatically altered in human malignancies. This wealth of knowledge has translated into molecularly defined targets for therapy over the past two decades, serving as key examples that translation of laboratory findings can have great impact on the ability to treat patients with cancer. However, given the genetic instability and...

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Identifiers

PMID: 24114654
DOI: 10.1002/path.4278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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