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Article

The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue.

PloS one - 1 Jan 2013

Drong Alexander W, Nicholson George, Hedman Asa K, Meduri Eshwar, Grundberg Elin, Small Kerrin S, Shin So-Youn, Bell Jordana T, Karpe Fredrik, Soranzo Nicole, Spector Tim D, McCarthy Mark I, Deloukas Panos, Rantalainen Mattias, Lindgren Cecilia M

Abstract excerpt

Genetic variants that associate with DNA methylation at CpG sites (methylation quantitative trait loci, meQTLs) offer a potential biological mechanism of action for disease associated SNPs. We investigated whether meQTLs exist in abdominal subcutaneous adipose tissue (SAT) and if CpG methylation associates with metabolic syndrome (MetSyn) phenotypes. We profiled 27,718 genomic regions in abdominal SAT samples of...

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Identifiers

PMID: 23431366
DOI: 10.1371/journal.pone.0055923
PMCID: PMC3576415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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