Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen receptor and by androgen-independent suppression of PTEN transcription in breast cancer

21 Oct 2011

Abstract excerpt

The tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10) plays important roles in tumor development and progression. Among many functions, PTEN negatively regulates the AKT anti-apoptotic signaling pathway, while nuclear PTEN affects the cell cycle by repressing the mitogen-activated protein kinase pathway. However, the regulation of PTEN expression is still not well understood. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Metastasis and carcinoma case studies
Share to PI3K/AKT/mTOR signaling in cancer
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22021428
DOI: 10.1093/hmg/ddr491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen receptor and by androgen-independent suppression of PTEN transcription in breast cancerPMID 22021428Read ↗

Gata3 antagonizes cancer progression in Pten-deficient prostatesSemantic proximity Read ↗

A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes.Semantic proximity Read ↗

GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complexSemantic proximity Read ↗

Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancerSemantic proximity Read ↗

Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis.Semantic proximity Read ↗

Regulation of Androgen Receptor Signaling by PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10) Tumor Suppressor through Distinct Mechanisms in Prostate Cancer CellsSemantic proximity Read ↗

GATA-4 Regulates Bcl-2 Expression in Ovarian Granulosa Cell TumorsSemantic proximity Read ↗

Phosphatase and Tensin Homologue Deleted on Chromosome 10 Deficiency Accelerates Tumor Induction in a Mouse Model of ErbB-2 Mammary TumorigenesisSemantic proximity Read ↗

Prostate Tumorigenesis Induced by PTEN Deletion Involves Estrogen Receptor β RepressionSemantic proximity Read ↗

Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing PerspectivesSemantic proximity Read ↗

ERBB2 Targeting Reveals a Significant Suppression of Tumorigenesis in Murine Endometrial Cancer with Pten Mutation.Semantic proximity Read ↗

Akt Blocks Breast Cancer Cell Motility and Invasion through the Transcription Factor NFATSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.