Article
Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease.
Blood - 4 Apr 2013
Wang Jiong-Wei, Bouwens Eveline A M, Pintao Maria Carolina, Voorberg Jan, Safdar Huma, Valentijn Karine M, de Boer Hetty C, Mertens Koen, Reitsma Pieter H, Eikenboom Jeroen
Abstract excerpt
Patients with von Willebrand disease (VWD) are often heterozygous for a missense mutation in the von Willebrand factor (VWF) gene. Investigating the pathogenic features of VWF mutations in cells directly derived from patients has been challenging. Here, we have used blood outgrowth endothelial cells (BOECs) isolated from human peripheral blood to analyze the storage and secretion of VWF. BOECs showed full...
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