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Article

Storage and secretion of naturally occurring von Willebrand factor A domain variants.

British journal of haematology - 1 Nov 2014

Groeneveld Dafna J, Wang Jiong-Wei, Mourik Marjon J, Dirven Richard J, Valentijn Karine M, Voorberg Jan, Reitsma Pieter H, Eikenboom Jeroen

Abstract excerpt

Von Willebrand disease (VWD) is a bleeding disorder characterized by reduced plasma von Willebrand factor (VWF) levels or functionally abnormal VWF. Low VWF plasma levels in VWD patients are the result of mutations in the VWF gene that lead to decreased synthesis, impaired secretion, increased clearance or a combination thereof. However, expression studies of variants located in the A domains of VWF are limited....

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Source

Identifiers

PMID: 25103891
DOI: 10.1111/bjh.13074

Genes

VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Storage and secretion of naturally occurring von Willebrand factor A domain variants.PMID 25103891Read ↗

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