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Article

Reduced von Willebrand factor secretion is associated with loss of Weibel-Palade body formation.

Journal of thrombosis and haemostasis : JTH - 1 May 2012

Castaman G, Giacomelli S H, Jacobi P M, Obser T, Budde U, Rodeghiero F, Schneppenheim R, Haberichter S L

Abstract excerpt

BACKGROUND: von Willebrand disease (VWD) is caused by mutations in von Willebrand factor (VWF) that have different pathophysiologic effect in causing low plasma VWF levels. Type 1 VWD includes quantitative plasma VWF deficiency with normal VWF structure and function. OBJECTIVES: We report three novel type 1 VWF mutations (A1716P, C2190Y and R2663C) located in different VWF domains that are associated with reduced...

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Identifiers

PMID: 22429825
DOI: 10.1111/j.1538-7836.2012.04702.x

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VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reduced von Willebrand factor secretion is associated with loss of Weibel-Palade body formation.PMID 22429825Read ↗

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