Article
Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells.
Blood - 4 Apr 2013
Starke Richard D, Paschalaki Koralia E, Dyer Clare E F, Harrison-Lavoie Kimberly J, Cutler Jacqueline A, McKinnon Thomas A J, Millar Carolyn M, Cutler Daniel F, Laffan Mike A, Randi Anna M
Abstract excerpt
Von Willebrand disease (VWD) is a heterogeneous bleeding disorder caused by decrease or dysfunction of von Willebrand factor (VWF). A wide range of mutations in the VWF gene have been characterized; however, their cellular consequences are still poorly understood. Here we have used a recently developed approach to study the molecular and cellular basis of VWD. We isolated blood outgrowth endothelial cells (BOECs)...
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