Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cells

1 Aug 2019

Abstract excerpt

BACKGROUND: Synthesis of the hemostatic protein von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel-Palade bodies (WPBs). In the absence of VWF, angiogenic and inflammatory mediators that are costored in WPBs are subject to alternative trafficking routes. In patients with von Willebrand disease (VWD), partial or complete absence of VWF/WPBs may lead to additional bleeding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation and Thrombosis Mechanisms
Share to Complement system in diseases
Share to Platelet Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31624792
DOI: 10.1002/rth2.12242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cellsPMID 31624792Read ↗

APOLD1 loss causes endothelial dysfunction involving cell junctions, cytoskeletal architecture, and Weibel-Palade bodies, while disrupting hemostasisSemantic proximity Read ↗

Multifaceted pathomolecular mechanism of a VWF large deletion involved in the pathogenesis of severe VWD.Semantic proximity Read ↗

Weibel-Palade bodies: a window to von Willebrand disease.Semantic proximity Read ↗

How to roll an endothelial cigar: the biogenesis of Weibel-Palade bodies.Semantic proximity Read ↗

FVIII interacts with cell surface to regulate endothelial cell functionalitySemantic proximity Read ↗

Von Willebrand disease and Weibel-Palade bodies.Semantic proximity Read ↗

Reduced von Willebrand factor secretion is associated with loss of Weibel-Palade body formation.Semantic proximity Read ↗

A Novel VWF Knockout Endothelial Cell Model to study von Willebrand Factor Biology and Von Willebrand Disease MechanismsSemantic proximity Read ↗

Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cellsSemantic proximity Read ↗

Thrombo-inflammatory endothelial signatures in <i>JAK2</i> -mutated myeloproliferative neoplasmsSemantic proximity Read ↗

Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease.Semantic proximity Read ↗

Dispatch and delivery at the ER–Golgi interface: how endothelial cells tune their hemostatic responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.