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Article

Lack of interaction of beta-cell-function-associated variants with hypertension on change in fasting glucose and diabetes risk: the Framingham Offspring Study.

Journal of hypertension - 1 May 2013

de Miguel-Yanes Jose M, Porneala Bianca, Pencina Michael J, Fox Caroline S, Florez Jose C, Siscovick David S, Dupuis Josée, Meigs James B

Abstract excerpt

OBJECTIVE: To test whether pancreatic beta-cell genetic frailty and hypertension (HTN) interact in their associations with change over time in fasting glucose (ΔFG) or type 2 diabetes mellitus (T2D) risk. METHODS AND RESULTS: We pooled data from 3471 Framingham Offspring Study participants into six ∼4-year periods (15 852 person-examinations; mean age 52; 54% women). We defined two genetic exposures reflecting...

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Share to Blood Glucose
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Insulin-Secreting Cells

Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 23425704
DOI: 10.1097/HJH.0b013e32835f5a83
PMCID: PMC3745997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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